Projection Structure of a N-Terminal Deletion Mutant of Connexin 26 Channel with Decreased Central Pore Density
نویسندگان
چکیده
منابع مشابه
NMR and structural data for Connexin 32 and Connexin 26 N-terminal peptides
In this article we present 1H and 13C chemical shift assignments, secondary structural propensity data and normalized temperature coefficient data for N-terminal peptides of Connexin 26 (Cx26), Cx26G12R and Cx32G12R mutants seen in syndromic deafness and Charcot Marie Tooth Disease respectively, published in "Structural Studies of N-Terminal Mutants of Connexin 26 and Connexin 32 Using 1H NMR S...
متن کاملtrans-dominant inhibition of connexin-43 by mutant connexin-26: implications for dominant connexin disorders affecting epidermal differentiation.
Dominant mutations of GJB2-encoding connexin-26 (Cx26) have pleiotropic effects, causing either hearing impairment (HI) alone or in association with palmoplantar keratoderma (PPK/HI). We examined a British family with the latter phenotype and identified a new dominant GJB2 mutation predicted to eliminate the amino acid residue E42 (DeltaE42) in Cx26. To dissect the pathomechanisms that result i...
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ژورنال
عنوان ژورنال: Cell Communication & Adhesion
سال: 2008
ISSN: 1541-9061,1543-5180
DOI: 10.1080/15419060802013588